Abstract
BackgroundSerial chest computed tomography (CT) scans are used to detect coronavirus disease 2019 (COVID-19) pneumonia and monitor the disease course. This study investigates relationship between total severity score by first chest CT and the outcome of coronavirus COVID-19 patients with coronary artery disease (CAD).ResultsA total of 48 patients with a history of CAD (mean age=60.83±3.06 years, 75% male) with positive real-time reverse transcription-polymerase chain reaction for COVID-19 were included. Outcome was defined as acute respiratory distress syndrome or death. The unadjusted and adjusted effects of the CT score on the outcome were reported through odds ratio (OR) with 95% confidence interval (CI). Outcome occurred in 17 (35.5%) patients (8 deaths). The CT score was directly and significantly correlated with the outcome in the univariate analysis (OR 1.38, 95% CI 1.12–1.70; P=0.003) and remained significant after adjustment for diabetes, hypertension, body mass index, and serum level of highly sensitive C-reactive protein (OR 1.51, 95% CI 1.11–2.05; P=0.009). Outcome rate was 24.1% in patients with a CT score <2.5, whereas it was 8.3% in patients with a CT score>2.5.ConclusionsThe first chest CT score could be a robust predictor of adverse events in confirmed COVID-19 patients with coronary artery disease.
Highlights
Serial chest computed tomography (CT) scans are used to detect coronavirus disease 2019 (COVID19) pneumonia and monitor the disease course
Chung et al [3] introduced a CT quantification severity score to measure the severity of lung involvement, with the score being generated based on inflammatory lung lesions ranging from 0 to 25
The aforementioned findings encouraged us to focus on the role of the first chest CT findings in predicting the outcome of reverse transcription-polymerase chain reaction (rRT-PCR)–confirmed COVID-19 patients with history of coronary artery disease (CAD)
Summary
Serial chest computed tomography (CT) scans are used to detect coronavirus disease 2019 (COVID19) pneumonia and monitor the disease course. This study investigates relationship between total severity score by first chest CT and the outcome of coronavirus COVID-19 patients with coronary artery disease (CAD). The outbreak of coronavirus disease 19 (COVID-19) originated in China in December 2019 and has continued ever since. This insidious disease is caused by a beta coronavirus named “severe acute respiratory syndrome coronavirus-2” [1]. Most recent studies on the COVID-19 pandemic have focused on descriptions of chest CT findings such as characteristic changes. The aforementioned findings encouraged us to focus on the role of the first chest CT findings in predicting the outcome of rRT-PCR–confirmed COVID-19 patients with history of CAD. We assessed the significance of the total severity score calculated on the basis of the first chest CT findings
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