Abstract
Objectives: To evaluate the possible anxiolytic activity of methanolic extract of Adhatoda vasica leaves (MEAVL) in Swiss albino mice. Methods: A total of 60 (n=60) mice were used. They were divided into ten groups of six mice each. The dose of 200, 400 and 600 mg/kg MEAVL were chosen after acute toxicity study. First 5 groups were evaluated by Elevated Plus Maze (EPM) and rest 5 group were evaluated by Light and Dark Arena (LDA) model. First group of mice (control) received 0.05ml/10g of Normal Saline, second group (standard) received 1.0 mg/kg Diazepam, third, fourth and fifth group received 200, 400 and 600 mg/kg of MEAVL respectively. Anti-anxiety effect was evaluated 60 min after the oral drug administration. Results: All the results were expressed in mean ± SD. One way ANOVA followed by Tukey- Kramer multiple comparison tests were used to compare between groups. In EPM model, the numbers of entries in open arm were 3.50±1.64, 13.17±7.44, 7.50±4.63, 3.67±1.86 and 4.67±2.94 respectively noted for 1st to 5th groups respectively for Normal Saline, Diazepam, 200, 400 and 600 mg/kg of MEAVL. Similarly in LDA model, the numbers of entries in dark arena were 12.17±1.47, 13.17±2.92, 12.33±3.01, 7.17±1.94 and 10.50±3.08 respectively noted for 6th to 10th group. This result clearly showed that MEAVL-400mg/KG has antianxiety property when compared to diazepam as evidenced by increase in the number of entries in dark arena in LDA model with p 0.05). Conclusion: The current study has demonstrated an antianxiety effect of MEAVL in a dose of 400mg/kg in LDA model. However, the study plant must be further evaluated to confirm the molecular basis of the antianxiety property so that it can be helpful for the society in the near future because of its antianxiety property.
Highlights
Anxiety disorders, the most common psychiatric illnesses in the general population
The dose range of 200, 400, and 600 mg/kg methanolic extract of Adhatoda vasica leaves (MEAVL) were selected for the present study
Elevated Plus Maze Test In EPM model, the numbers of entries in open arm were 3.50±1.64, 13.17±7.44, 7.50±4.63, 3.67±1.86 and 4.67±2.94 respectively noted for 1st to 5th groups respectively for Normal Saline, Diazepam, 200, 400 and 600 mg/kg of MEAVL
Summary
The most common psychiatric illnesses in the general population. Around 15–20% patients in general practice present with anxiety disorders. It is characterized by excessive rumination, worrying, uneasiness, apprehension and fear about future uncertainties either based on real or imagined events, which may affect both physical and psychological health. Numerous studies have shown that patients with anxiety disorders over-estimate the dangerousness of various stimuli. Current psychiatric diagnostic criteria recognize a wide variety of anxiety disorders. Recent surveys have found that as many as 18% of Americans, 20.7% of Indians and 14% of Europeans may be affected by one or more of them. Recent surveys have found that as many as 18% of Americans, 20.7% of Indians and 14% of Europeans may be affected by one or more of them. [1]
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