Abstract
ObjectivesTo determine the feasibility of pre-treatment primary tumor FDG-PET and DWI-MR imaging parameters in predicting HPV status and the second aim was to assess the feasibility of those imaging parameters to predict response to therapy. Material and MethodsWe retrospectively analyzed primary tumors in 33 patients with proven OPSCC. PET/MRI was performed before and 6 months after chemo-radiotherapy for assessing treatment response. PET Standardized uptake value (SUVmax), total lesion glycolysis (TLG), metabolic tumor volume (MTV), and apparent diffusion coefficient (ADC) from pre-treatment measurements were assessed and compared to the clinicopathological characteristics (T stages, N stages, tumor grades, HPV and post-treatment follow up). HPV was correlated to the clinicopathological characteristics. ResultsADCmean was significantly lower in patients with HPV+ve than HPV-ev, (P = 0.001), cut off value of (800 ± 0.44*10-3mm2/s) with 76.9% sensitivity, and 72.2% specificity is able to differentiate between the two groups. No significant differences were found between FDG parameters (SUVmax, TLG, and MTV), and HPV status, (P = 0.873, P = 0.958, and P = 0.817), respectively. Comparison between CR and NCR groups; ADCmean, TLG, and MTV were predictive parameters of treatment response, (P = 0.017, P = 0.013, and P = 0.014), respectively. HPV+ve group shows a higher probability of lymph nodes involvement, (P = 0.006) ConclusionOur study found that pretreatment ADC of the primary tumor can predict HPV status and treatment response. On the other hand, metabolic PET parameters (TLG, and MTV) were able to predict primary tumor response to therapy.
Highlights
There is an increasing incidence worldwide for reporting aggressive oropharyngeal squamous cell carcinoma (OPSCC) [1]
The SUVmax, total lesion glycolysis (TLG), metabolic tumor volume (MTV) and ADCmean measured from the primary tumors were 12.61 ± 0.5; 139 ± 0.87, 15 ± 0.14 and 0.820 ± 1.12*10-3mm2/s, respectively
We analyzed the efficacy of combined Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) imaging parameters to predict HPV status and local response of OPSCC treated by CRT with curative intent
Summary
There is an increasing incidence worldwide for reporting aggressive OPSCC [1]. Alcohol and tobacco are the most etiological factors of developing OPCCS [2,3]. It has been found that high-risk sexual behavior is a growing factor for increasing HPV-positive especially among young people [4]. There are several biological, clinical, and epidemiological to distinguish HPV-positive from HPV-negative entities [5]. Previous studies have demonstrated that patients with positive HPV have been shown better response to therapy and better survival. Compared to negative HPV [6,7,8].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
