Abstract

ObjectiveThis study aimed to assess the duration of pre-hospital delay among ST-Segment Elevation Myocardial Infarction (STEMI) patients and its contributing factors.MethodologyA cross-sectional study was conducted at Rural Satellite Center in Larkana, Pakistan from May to September 2020. A total of 240 STEMI patients who underwent primary percutaneous coronary intervention (P-PCI) were included. The patients' demographic characteristics, index event characteristics, mode of transportation, misinterpretations, misdiagnoses, and financial problems were recorded. Data were analyzed using SPSS version 22.0 (IBM Corp., Armonk, NY, USA).ResultsThe observed pre-hospital time was 120 minutes; 229 (median; interquartile range [IQR]). It was found that 33.3% of patients arrived within one hour of the symptom onset, while 20.4% of patients delayed hospital arrival for more than six hours. The delay rate was highest among patients aged 41 to 65 years. Moreover, delayed admissions were more common among females as compared to males (p=0.008). Among the causes of delay in hospital arrival were misinterpretation, misdiagnosis, and transportation and financial issues. Of these, misdiagnosis significantly influenced the delay rate, i.e., more than 50% of the misdiagnosed patients arrived hospital after six hours of symptom onset (p<0.05).ConclusionThe P-PCI rural satellite center had a positive impact as the observed pre-hospital delay rate was considerably less as compared to that reported in the existing literature. Moreover, the confounding factors were misdiagnosis and misinterpretations. We need to develop the concept of immediate appropriate help-seeking among patients.

Highlights

  • Acute Myocardial Infarction (AMI) remains a medical emergency and a common cause of mortality worldwide

  • This study aimed to assess the duration of pre-hospital delay among ST-Segment Elevation Myocardial Infarction (STEMI) patients and its contributing factors

  • It was found that 33.3% of patients arrived within one hour of the symptom onset, while 20.4% of patients delayed hospital arrival for more than six hours

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Summary

Introduction

Acute Myocardial Infarction (AMI) remains a medical emergency and a common cause of mortality worldwide. Thrombolysis should not be delayed for more than 30 minutes, and PCI to be performed within 90 minutes after arrival at the hospital (door-to-needle time and door-to-balloon time). Primary PCI (P-PCI) is considered superior to thrombolysis [3] as P-PCI has proven to be more efficacious for the cases with prolonged onsets to hospital arrival time. Many developing countries present the facility of PPCI capable hospitals with acceptable door-to-balloon time (DBT) [6,7]. Despite all these efforts, no significant reduction in the TIT has been observed until now as the pre-hospital delays, i.e., symptom-to-

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