Abstract
Oligoribonucleotides-D-mannitol (ORNs-D-M) complexes possess antiviral, anti-inflammatory, and immunomodulatory actions. The aim of the present study was to evaluated an antiviral effect of ORNs-D-M against parainfluenza virus type 3 (PIV3); influenza CA709, PR834; avian influenza virus H5N2 (AIV) in vitro by a TCID50; hemadsorption and neuraminidase activity assays; and clinical efficiency of ORNs-D-M in patients with acute respiratory infections (ARIs) of various etiologies by PCR assay and AmpliSens test systems. It was observed that ORNs-D-M have an antiviral activity against the influenza CA709, PR834, PIV3, and AIV in vitro. The injectable dosage form of ORNs-D-M was shown to have a stronger antiviral effect compared to capsule form. It was also detected that the injectable form of ORNs-D-M significantly reduced the neuraminidase activity of influenza PR834. A complex treatment of patients with ORNs-D-M had a positive effect on the course of the disease, it accelerated patients’ recovery. Treatment with ORNs-D-M caused eradication of adeno- and influenza viruses in patients with ARI. This drug contributed to significant decrease in duration of febrile period and cough. Comprehensive treatment with ORNs-D-M improved the disease clinical findings significantly. Collectively, these results suggested that ORNs-D-M may be used at co-infection with influenza and other respiratory viruses as a medical antiviral drug.
Highlights
Influenza and other acute respiratory infections (ARIs) are the most common human diseases and are nearly 70% of all infectious diseases
ARIs have traditionally been thought to be caused by single viruses, an increasing number of reports have reported respiratory diseases occurring as dual or multiple virus infections [11,12,13,14,15,16]
Antiviral effect of ORNs-D-M capsule and injection forms against the parainfluenza virus type 3 (PIV3) in vitro was determined by their ability to inhibit a hemadsorption activity of Human epithelial type 2 (HEp2) cells, that was infected with PIV3, and the PIV3 infectivity
Summary
Influenza and other acute respiratory infections (ARIs) are the most common human diseases and are nearly 70% of all infectious diseases. Viruses are the leading causes of acute respiratory disease throughout the world. The most common viral etiologic agents of ARIs are respiratory syncytial virus (RSV), human metapneumovirus (MPV), influenza A and B viruses, parainfluenza viruses (PIV 1-2-3) and adenoviruses (AdV), human rhinoviruses (RV), human coronaviruses (CoV), enteroviruses (EnV), and human bocavirus (BoV) [7,8,9]. ARIs have traditionally been thought to be caused by single viruses, an increasing number of reports have reported respiratory diseases occurring as dual or multiple virus infections [11,12,13,14,15,16]. There are suggestions that respiratory viral co-infections affect disease severity with some studies suggesting that dual and multiple infections increase the severity of respiratory disease [12,14,16], while dual or multiple infections may be protective [13]
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