Abstract
Pre- and postsynaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis.
Highlights
To cite this version: Dominique Debanne, Oussama El Far
In more than a third of limbic encephalitis patients who test positive in this assay, the immunoprecipitating autoantibodies are directed against LGI1, a secreted glycoprotein composed of a leucine-rich N-terminal domain (LRR) and a C-terminal bpropeller known as the epitempin domain (EPTP)
In a recent report it has been shown that in Lgi–/– animals, the increase in neuronal excitability results from a massive decrease in axonal and presynaptic Kv1 channel expression (Seagar et al, 2017). This downregulation presumably occurs earlier than the perturbation of AMPA receptor expression. These data suggest that LGI1 regulates action potential firing by setting the density of the axonal Kv1 channels that underlie DTx-sensitive D-type potassium current
Summary
To cite this version: Dominique Debanne, Oussama El Far. Pre-and postsynaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis. This scientific commentary refers to ‘LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory’, by Petit-Pedrol et al (doi:10.1093/ brain/awy253). A subset of autoimmune limbic encephalitis patients possess autoantibodies that immunoprecipitate a protein complex containing the dendrotoxin (DTx) target potassium channel (Kv1).
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