Abstract
The transcription factor c-JUN is an important regulator of malignant transformation and tumor progression. Phosphorylation plays a central role in controlling the activity of c-JUN, and while a variety of kinases have been reported to target c-JUN, the contribution of phosphatases has been poorly defined. We identified a specific role for PR55a-containing PP2A complexes in dephosphorylating the C-terminus of c-JUN to promote its binding to target genes, including regulators of cell migration, invasion and epithelial mesenchymal transitions. Taken in the context of previous work implicating PR55a as a positive regulator of the WNT and TGFb pathways, our findings suggest that PR55a-PP2A complexes may coordinate multiple signaling and transcriptional events involved in tumor progression.
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