PP162: Superselective intra-arterial chemotherapy for oral cancer with implanted infusion reservoir: A new chemotherapy method to improve both the curative effect and the ouality of life

Abstract

Introduction We have developed a superselective intra-arterial chemotherapy (iaCT) approach for oral cancer, in which intra-arterial catheter is retrogradely inserted via the superficial temporal artery (STA) and/or occipital artery (OA). This approach increases curative effect but remarkably decreases activities of daily living (ADL) because the catheter penetrates the skin over the approaching artery, tempral area and/or occipital area. Purpose We device the method to improve the ADL of patients with intra-arterial catheter by subcutaneous implantation of an intra-arterial catheter connected to a subcutaneous infusion reservoir. Materials and methods We have used this approach for 46 patients who had oral cancer treated using iaCT. In this approach, the catheter was superselectively placed in the tumor-feeding artery by cut-down of STA and/or OA. The extra-arterial portion of catheter was connected to a infusion reservoir implanted subcutaneously around the mastoid process through the subcutaneous tunnel. The catheter and reserver was completely placed under the skin, so there was little possibility of catheter-related infection and displacement of catheter from intended position. The chemotherapeutic agent was intra-arterially administered through the reservoir by penetration the overlying skin with Huber needle. Results This method have improved the ADL of patients without the least loss of curative effect. It is enebled even to discharge the Hospital and to receive out-patient chemotherapy, while they continue almost the same lifes as former days. Conclusions In this approach, the catheter is completely implanted subcutaneously; therefore, usual catheter-related issues (e.g., infection, catheter fall out) rarely occur. Because this leads to very good ADLs, even outpatient chemotherapy can be safely performed.