Abstract
The granular cell tumor is an uncommon benign neoplasm, which most commonly occurs in the head and neck region. In the oral cavity, the tongue is the most common site. This report describes a case of granular cell tumor of the buccal mucosa. The patient, a 60-year-old woman was referred for evaluation of a nodule located in the buccal mucosa, with duration of approximately 3 months. Intraoral examination revealed a slightly yellowish, painless, binodular lesion measuring approximately 0.5 cm, located in the buccal mucosa. A mesenchymal benign neoplasm was the main diagnostic hypothesis. Under local anesthesia, the lesion was excised. Microscopically, numerous round cells with small central nuclei, and large, granular eosinophilic cytoplasm were observed. No cellular atypia, mitoses or necrosis were noted. However, perineural invasion was observed. Thus, the final diagnosis was granular cell tumor. Although uncommon, the granular cell tumor should be considered in the differential diagnosis of submucosal nodules located in the buccal mucosa.
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