PP.27.02

Abstract

Objective: To compare the relationship of endothelial dysfunction, systolic and diastolic blood pressure (BP), and body mass index (BMI) in patients with coronary heart disease in combination with nonalcoholic fatty liver disease (NAFLD). Design and method: We studied 21 patients with coronary heart disease in combination with NAFLD mean age 54,8 ± 5,04 (group A) and 10 patients with coronary heart disease without NAFLD mean age 57,6 ± 4,7 (group B). Patients with diabetes were excluded. The reactive hyperemia test for assessment of endothelial dysfunction was consecutively performed in all patients. Studied biochemical parameters: aspartate transaminase (AST), gamma-glutamyl transpeptidase (GGT). Results: According to the reactive hyperemia test data, endothelial dysfunction was found in 19 patients (90%) in a group A and in 5 patients (50%) in a group B, vasospastic response observed in 2 patients (9,5%) in a group A. Reactive hyperemia index was lower (4,94 ± 4,3%,) in the group A than in group B (9,3 ± 3,4%) (p < 0,05). The mean level systolic BP in a group A was higher (150,2 ± 5,8 mm Hg) than in group B (131,3 ± 4,4) (p < 0,05). The mean level diastolic BP changes did not significantly differ between the two groups (93,4 ± 8,4 mm Hg and 93,8 ± 6,4 mm Hg, p = 0,54). The mean level of BMI: 31,7 ± 5,01 kg/m2 in group A, 27,1 ± 2,5 kg/m2 in a group B (p < 0,05); of AST: 25,8 ± 4,1mmol/l and 20,4 ± 3,14mmol/l (p < 0,05); of GGT 61,4 ± 8,1mmol/l and 28,3 ± 4,2mmol/l (p < 0,05). There was correlation between the endothelial dysfunction, level of AST (r = 0,58; p < 0,05) and level of GGT (r = 0,55; p < 0,05) in a group A however in a group B such connection was not observed. The level of diastolic BP in a group A associated with level GGT (r = 0,60; p < 0,05), body mass index (r = 0,48; p < 0,05), level of systolic BP (r = 0,78; p < 0,05) than in group B. Conclusions: In patients with NAFLD in combination with coronary heart disease endothelial dysfunction were more expressed than in those who had no NAFLD. The mean level systolic BP in a group A was higher than in group B.