Abstract
Spontaneous field potential oscillations were recorded from the CA3 distal apical dendritic region of guinea pig hippocampal slices maintained in ‘normal’ artificial cerebrospinal fluid in vitro. Power spectral analysis revealed a mixture of frequencies mainly under 20 Hz without distinct peaks. High concentrations of extracellular Mg 2+ blocked the activity. These findings suggest that the intrinsic spontaneous activity of the hippocampus is produced by partially synchronized synaptic potentials. This in vitro system may provide a suitable model for studying the mechanisms underlying the generation of EEG rhythms.
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