Abstract
Published data from this and other laboratories support the hypothesis that central postsynaptic serotonin (5-HT) receptor activity may be involved in some types of depression (Aprison and Hingtgen 1981, 1986; Aprison et al 1978, 1982; Hingtgen et al 1985, 1989; Mayeda et al 1989; Stockert et al 1988; Takahashi et al 1982). Some recent clinical studies have also supported this concept (Yates et al 1990; Arora and Me|tzer 1989) whereas others have not (Cheetham et al 1988: Crow et al 1984). Evidence of upregulation of 5-HT receptors has been demonstrated in various behavioral models of depression (Takahashi et al 1982; Mayeda et al !989). Furthermore, some studies in which the 5-HT system was selectively lesioned w;th chemical agents found upregulation of 5-HT~ receptors 14 or more days after the lesion (Blackburn et al 1981; Quik and Azmitia 1983). In the present study we tested the effects of 5,7-dihydroxytryptamine (5,7-DHT)-induced
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