Abstract
Abstract Major blood anticlotting agents may be grouped into two classes: 1) heparin and heparin analogs, 2) coumarin and coumarin analogs. The first class of compounds interferes with the formation of thrombin and thromboplastin whereas the second inhibits the formation of prothrombin. Both classes have their own antagonists; namely, protamine sulfate types and vitamin K types exhibiting antihemorrhagic properties. On a molecular level the heparinlike structures and their antagonists may be regarded as polyanions and polycations, respectively, whereas the coumarinlike structures and their antagonists as electron donors and acceptors, respectively, which may form charge transfer complexes.
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