POTENTIAL USE OF ROUTINE CSF PARAMETERS FOR THE DIFFERENTIAL DIAGNOSIS OF DEMENTIA DISEASES

Abstract

netics, Ghent, Belgium). ROC curve analyses were performed to assess diagnostic power. Added diagnostic value was explored by comparing the Ab isoforms performance to the performance of the core AD CSF biomarkers: Ab 1-42, T-tau and P-tau 181P. Results: The Ab isoforms levels correlated moderately with MMSE scores and disease duration in the dementia due to AD group, suggesting a correlation with disease progression. CSF Ab 1-42 levels were lower in e4 carriers as compared to non-carriers. The diagnostic value of the Ab 1-42/Ab 1-40 ratio was better than the diagnostic performance of Ab 1-42 in most differential situations. The best biomarkers to discriminate dementia due to AD from FTDwereAb 1-42/Ab 1-37 and the relative value of Ab 1-42 (AUC1⁄4 0.851 and 0.831 respectively). The best biomarkers to distinguish dementia due to AD and DLBwere Ab 1-42/Ab 1-38 and Ab 1-42/T-tau (AUC 1⁄4 0.843 and 0.838 respectively). Conclusions: In conclusion, Ab isoforms increase the diagnostic performance of Ab 1-42 and they are of help for differential dementia diagnosis, especially to differentiate FTD and DLB from AD and to diagnose AD in patients with normal Ab 1-42 levels. Furthermore, in contrast to Ab 1-42, Ab isoforms are correlated with disease severity in AD.