Abstract
Natural killer (NK) cell is a type of immune cell and is known to be particularly responsible for innate immunity such as anti-cancer immunity, defense mechanisms against infections, and secretion of various cytokines and chemokines for increasing recruitment of other immune cells. In this study, we investigated the potentials of NK-enriched lymphocytes (NKEL) conditioned media (CM) on skin care for cosmeceutical compositions. Various cytokines of NKEL CM can improve wound healing through epithelial-mesenchymal transition (EMT) by increasing KLKs (kallikreins) and reduce metalloproteinase (MMP)-1 and MMP-2 to inhibit wrinkle formation. Our results suggest that NKEL CM which has various cytokines promotes up-regulation of cell migration and KLKs and down-regulation of MMP-1 and MMP-2 by stimulating HaCaT keratinocytes migration. Therefore, NKEL CM can be used as a cosmetic composition that can play a role in skin regeneration and anti-aging.
Highlights
With the improvement of living standards and the increased demand for beauty, interest in skin beauty is increasing day by day [1] [2]
Our results suggest that NK-enriched lymphocytes (NKEL) conditioned media (CM) which has various cytokines promotes up-regulation of cell migration and KLKs and down-regulation of MMP-1 and MMP-2 by stimulating HaCaT keratinocytes migration
These results show that NKEL CM decreases the expression levels of MMP-1 and MMP-2, and it can be said to mean that it inhibits aging in skin beauty through the anti-wrinkle effect
Summary
With the improvement of living standards and the increased demand for beauty, interest in skin beauty is increasing day by day [1] [2]. In response to these demands, researchers are working on finding new, more effective, bioactive, and biocompatible anti-aging compounds in the pharmaceutical and cosmeceutical field [3]. The aging phenomenon is an inevitable process that occurs when the growth and development of the body stops, and it means changes in body composition and function of each organ [4]
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