Abstract
Long-chain ω-3 polyunsaturated fatty acids (PUFAs) are fundamental biocomponents of lipids and cell membranes. They are involved in the maintenance of cellular homeostasis and they are able to exert anti-inflammatory and cardioprotective actions. Thanks to their potential beneficial effects on the cardiovascular system, metabolic axis and body composition, we have examined their action in subjects affected by male obesity secondary hypogonadism (MOSH) syndrome. MOSH syndrome is characterized by the presence of obesity associated with the alteration of sexual and metabolic functions. Therefore, this review article aims to analyze scientific literature regarding the possible benefits of ω-3 PUFA administration in subjects affected by MOSH syndrome. We conclude that there are strong evidences supporting ω-3 PUFA administration and/or supplementation for the treatment and management of MOSH patients.
Highlights
It is truly fascinating to study how lifestyle modification can alter the course of a disease by modifying genetic expression and protein synthesis patterns
We can distinguish between saturated fatty acids (SFAs), which are characterized by the absence of double bonds, monounsaturated fatty acids (MUFAs), which only have one double bond and polyunsaturated fatty acid (PUFA), in which more than one double bond may be found
40 apolipoprotein E (ApoE) (-/-) knockout mice randomized into 5 groups: 1 control group fed normal chow diet, 4 groups fed chow diet supplemented with 200 mg/kg/day of (i) docosahexaenoic acid (DHA), (ii) eicosapentaenoic acid (EPA), (iii) linoleic acid (LA) or (iv) arachidonic acid (AA), for DHA supplementation reduced the expression of vascular cell adhesion molecule (VCAM)-1 in a dose-dependent manner in tumor necrosis factor-α (TNF-α) -activated aortic endothelial cells
Summary
It is truly fascinating to study how lifestyle modification can alter the course of a disease by modifying genetic expression and protein synthesis patterns. Researchers have found that changes in daily habits coupled with healthy nutrition can literally modulate our gene expression, in order to achieve better metabolic profiles and decrease the risk of developing an array of diseases [1]. Exploring the properties of natural compounds such as ω-3 polyunsaturated fatty acids (PUFAs) and how they can be optimally integrated in the diet is of paramount importance. PUFA ω-3 would seem to exert a cardioprotective role as they improve heart rate variability, a non-invasive marker of cardiac autonomic system function, with a subsequent reduction in the risk of sudden cardiac death and arrhythmias [2]. A further beneficial effect induced by PUFAs is linked to Nutrients 2020, 12, 2519; doi:10.3390/nu12092519 www.mdpi.com/journal/nutrients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
