Abstract
Pharmacological resistance to synthetic anthelmintic drugs is an important barrier to the control of animal parasites. Thus, this study aimed to evaluate the anthelmintic action of the hydroalcoholic extract of banana bracts (HEB) at 10%. Concentration. Hatch test and larval migration inhibition test (LMI) were performed. Additionally, the total content of polyphenols, condensed tannins, and flavonoids was determined, along with the antioxidant activity of HEB. In relation to bovine species, HEB at a concentration of 2.5 mg mL-1 inhibited hatchability of nematode larvae by 88%. The LMI indicated 67.56% inhibition with 5 mg mL-1 HEB. However, in sheep, HEB did not show an influence in either tests. The HEB (10 mg mL-1) had 0.38 mg EAG g-1 of total polyphenols, 372.70 mg EAT g-1 tannins, 0.42 mg RE g-1 flavonoids, and presented antioxidant activity at 43.03% with IC 50 corresponding to 0.2765 mg mL-1. Thus, HEB presents anthelmintic potential in vitro, for the control of verminosis in cattle, in addition to demonstrating antioxidant activity. These results are particularly important for agroecological, organic, and biodynamic systems of animal production, considering that the use of synthetic parasiticides is not allowed in these systems.
Highlights
Gastrointestinal nematodes are one of the main economic barriers in sheep and cattle production
This study aimed to evaluate the anthelmintic action of the hydroalcoholic extract of banana bracts (HEB) at 10%
HEB presents anthelmintic potential in vitro, for the parasitologic control in cattle, in addition to demonstrating antioxidant activity. These results are important for agroecological, organic, and biodynamic systems of animal production, considering that the use of synthetic parasiticides is not allowed in these systems
Summary
Gastrointestinal nematodes are one of the main economic barriers in sheep and cattle production. Verminosis can lead to losses via decrease in weight gain, increase in mortality rate, lower carcass yield, lower meat, and milk and wool production, in addition to expenditure on medicines (MORGAN et al, 2013). These parasites are frequently controlled by the use of synthetic parasiticides. 8; TARIQ, 2017), use of multiple and regular doses of anthelmintics is increasingly observed, causing negative effects on the development of natural immunity in the animals, and promoting even more parasitic resistance to various chemical groups (CROOK et al, 2016; SANTOS et al., 2017). This resistance has been observed worldwide (KANETO et al, 2016; MUCHIUT et al, 2018), and the widespread use of parasiticides has resulted in the presence of medicinal residues in foodstuffs of animal origin, as well as in the environment (SMITH et al, 2013).
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