Abstract
In order to study the relationship between potassium excretion and that of the main urinary buffer, i.e. phosphate, rat micropuncture experiments were carried out. The effects of acute potassium loading and chronic potassium depletion on phosphate transport along superficial nephrons were evaluated: marked antiphosphaturia was observed in both conditions. Whereas an impaired renal response to parathyroid hormone (PTH) in potassium depletion had already been described (1) it was not known whether such a mechanism might be involved in acute hyperkalemia. Hence, in an additional series of clearance experiments during acute hyperkalemia, the effect of parathyroidectomy on the potassium-induced reduction of phosphate excretion was also assessed.
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