Postprandial lipemia and endothelial function in active and sedentary menes

Abstract

Postprandial lipemia's effect on endothelial function in active and sedentary men without the influence of a recent bout of exercise has not been studied. Nine active and 8 sedentary males (18–38 yr old with VO2 peaks 64.1 and 39.4 mL/kg/min) drank a high fat dairy shake after a 12 h fast and 36 h of inactivity. Blood was collected and brachial artery flow mediated dilation (FMD) was determined by b‐mode ultrasound at 0, 3 and 6 h. Serum glucose remained stable but, non‐esterified fatty acids increased in both groups over time. Total cholesterol (TC) and triglycerides (TG) were highest at 3 h, TG did not return to fasting levels after 6 h, both groups were not statistically different (TG: 67.7±6.5, 107.9±9.5, 83.5±8.9 mg/dL and TC: 158.2±7.2, 164.4±7.0, 162.7±7.0 mg/dL at 0, 3 and 6 h respectively). Height adjusted baseline brachial diameter at 0 h was larger in the active group (4.9±0.1 Active, 4.1±0.1 mm Sedentary). Age adjusted %FMD was not different except at 6 h with sedentary being greater. The %FMD peaked at 3 h for active and 6 h in the sedentary group (Active: 4.4±0.5, 4.9±1.0, 4.0±1.0, Sedentary: 7.1±1.2, 7.7±1.6, 8.8±2.0mm at 0, 3, 6 h). Studies on postprandial lipemia need to control for recent exercise as fitness level did not alter postprandial lipemia with 36 h of inactivity. Postprandial lipemia did not alter endothelial function differently but active males had a larger vessel at rest. MDRF Grant, Univ. at Buffalo