Postprandial hypolipidemic and hypoglycemic effects of Allium hertifolium and Sesamum indicum on hypercholesterolemic rabbits

Abstract

Oxidative stress associated with postprandial hyperlipidemia contributes to endothelial dysfunction, which shifts hemostasis to a more thrombogenic state. The present study was undertaken to evaluate the effect of Allium hertifolium and Sesamum indicum on postprandial lipemic, glycemic profile and endothelial markers in hypercholesterolemic rabbits. A total of 32 male rabbits were randomized into 4 groups: Group 1: Control group (normal group); Group 2: Hypercholesterolemic diet (1% cholesterol); Group 3: 1% cholesterol administered with A. hertifolium extract (2% of diet); Group 4: 1% cholesterol administered with S. indicum powder (10% of diet). The serum was analyzed for lipid profile (total cholesterol (TC); triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), ApoB), glucose, nitrite, nitrate, serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) levels and plasma was analyzed for fibrinogen and factor VII. These factors were measured in blood samples following 15 h of fasting and 3 h after feeding. The results showed A. hertifolium andS. indicum to be effective in reducing SGPT, fibrinogen, total cholesterol (TC) and LDL-C values in comparison with hypercholesterolemic diet group. Consumption of A. hertifolium and S. indicum did not significantly change factor VII, ApoB and nitrite levels in comparison with hypercholesterolemic diet group. Intake of S. indicum significantly decreased serum SGOT, nitrate, glucose and TG compared to hypercholesterolemic diet group. A. hertifolium and S. indicum with a high content of phenolic compounds change the postprandial profile lipids, endothelial markers and trombogenic factors and might be beneficial in patients with cardiovascular diseases. Key words: Allium hertifolium, Sesamum indicum, postprandial, serum glutamic pyruvic transaminase (SGPT).