Postoperative AdjuvantTranscatheter Arterial Chemoembolization After R0 Hepatectomy Improves Outcomes of Patients Who have Hepatocellular Carcinoma with Microvascular Invasion.

Abstract

Microvascular invasion (MiVI) is a major risk factor of survival outcomes after curative resection for patients with hepatocellular carcinoma (HCC). This study aimed to investigate the impact of postoperative adjuvanttranscatheter arterial chemoembolization (PA-TACE) on HCC patients with MiVI. From January 2004 to June 2013, HCC patients with histologically confirmed MiVI and well-tolerated liver function who underwent PA-TACE after R0 hepatectomy (RH) or RH alone were studied retrospectively. In the PA-TACE group, PA-TACE was given 4weeks after RH. Uni- and multivariate analyses were used to identify the prognostic significance of PA-TACE. Of the 322 HCC patients with MiVI included in the analysis, 185 entered into the RH group and 137 entered into the PA-TACE group. The baseline characteristics of the two groups were similar except for alanine aminotransferase (ALT) level (p=0.037). The 1-, 2-, 3-, and 5-year recurrence-free survival (RFS) rates were respectively 69.3, 55.5, 46.7, and 35.0% for the PA-TACE group and 47.0, 36.2, 34.1, and 30.3% for the RH group (log-rank, χ(2)=6.309; p=0.012). The 1-, 2-, 3-, and 5-year overall survival (OS) rates were respectively 94.2, 78.8, 71.5, and 54.0% for the PA-TACE group and 78.9, 62.2, 54.1, and 43.2% for the RH group (log-rank, χ(2)=7.537; p=0.006). Multivariate Cox proportional hazards regression analysis showed PA-TACE to be an independent risk factor of postoperative RFS and OS. This study showed that PA-TACE may be beneficial for HCC patients with MiVI.