Abstract
In this study, we assessed the roles of postnatal lymphotoxin (LT)-α mediated signaling in the maintenance of the microarchitecture of the fully developed spleen. To investigate the role of postnatal LT-α-mediated signals in the organization of splenic microarchitecture, wild-type (LTα+/+) mice were lethally irradiated and then reconstituted with LT-α deficient (LTα-/-) bone marrow. The transfer of LTα-/- bone marrow to those mice resulted in the disruption of splenic microarchitecture, including the segregation of T and B cell areas, and the formation of germinal centers and follicular dendritic cell clusters. In contrast, adoptive transfer of LTα+/+ bone marrow to LTα-/- mice restored the segregation of T and B cell areas and the formation of the germinal center and follicular dendritic cell cluster in the spleen. These results suggest that the maintenance of splenic microarchitecture is not programmed during development but is dependent on constant stimuli provided by LTα.
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