Poster No. 095 The predictors of clinical outcome in the patients undergoing endovascular intervention for lower extremity peripheral arterial disease

Abstract

Abstract Background Patients with peripheral arterial disease (PAD) have a higher mortality rate than patients without PAD. This study aimed to identify the predictors of mortality outcomes in patients with peripheral artery disease undergoing lower extremity endovascular interventions. Materials and methods We studied 300 consecutive patients admitted for symptomatic PAD. A 196 patients without angina and prior coronary revascularization (72 ± 10 years, 156 men) who underwent lower extremity endovascular intervention (claudication, n = 74; critical limb ischemia, n = 122) were retrospectively analyzed. Results: During follow-up, all-cause mortality and MACCE at 3 year were 16.3% and 19.8%, respectively. The independent risk factors for all-cause mortality were old age (HR = 1.05, P = 0.043), lower body mass index (HR = 0.83, P = 0.016), critical limb ischemia (HR = 3.74, P = 0.033) and the presence of CAD (HR = 2.85, P = 0.027). This variable surpassed all classical risk factors (including smoking and history of hypertension or diabetes mellitus). Of the 196 patients, 101 patients (52%) had asymptomatic CAD; 1-VD (n = 35, 18%); 2-VD (n = 32, 16%); 3-VD (n = 28, 14%). At 3 year follow-up, patients with CAD had significantly higher all-cause mortality (19% vs. 11%, P = 0.018) and higher MACCE rate (26% vs. 8%, P = 0.001) compared to those without CAD. Conclusions Asymptomatic coronary artery disease (CAD) was found in half of the patients undergoing endovascular intervention for PAD and associated with higher mortality and MACCE rate. Therefore, detection of CAD might be important for risk stratification for these patients, especially with lower body mass index or critical limb ischemia.