Abstract
Purpose: The use of platelet-rich plasma (PRP) is one of the therapeutic strategies clinically available to promote bone repairing and wound healing. Platelets contain various growth factors, such as platelet-derived growth factor (PDGF), transforming growth factors (TGF-beta1 and -beta2), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (b-FGF). It is demonstrated that when platelets are activated, the growth factors are released from them and contribute to bone regeneration. Recently, some clinical articles have been reported on the application of the PRP in the oral and maxillofacial surgery. Among them, the PRP is mainly used combined with the fibrin. However, little has been investigated on the combination materials of PRP from the viewpoint of the biological function enhancement. We have demonstrated that biodegradable gelatin hydrogels are effective as a carrier for the controlled release of b-FGF, VEGF, and TGF-beta1 to enhance their biological functions. The objective of the present study is to investigate potentiality of the gelatin hydrogel in promoting the bone repairing activity of PRP with bone defect model.
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