Abstract
A human sperm-specific protein has been isolated that may prove useful in the development of a contraceptive vaccine.
Highlights
Contraception has always been an important area of reproductive biology research, and there are ongoing efforts to develop less expensive, more efficient and more administered methods
The authors demonstrated that TSA-1 mRNA does not seem to be expressed in any of 18 major organs and tissues other than the testis
The protein product is expressed at several points along the surface of mature human spermatozoa, predominantly at the acrosomal, equatorial, mid-piece and tail regions of capacitated and non-capacitated cells
Summary
Contraception has always been an important area of reproductive biology research, and there are ongoing efforts to develop less expensive, more efficient and more administered methods. The authors demonstrated that TSA-1 mRNA does not seem to be expressed in any of 18 major organs and tissues other than the testis. The protein product is expressed at several points along the surface of mature human spermatozoa, predominantly at the acrosomal, equatorial, mid-piece and tail regions of capacitated and non-capacitated cells.
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