Abstract
The mechanism of clonidine-induced vasodilatation was investigated in the isolated and perfused canine coronary arteries. Clonidine produced a slight vasoconstriction at small doses whereas it induced a dose-related vasodilatation at large doses (more than 3 μg). The vasodilatation was reversed to vasoconstriction by treatment with 100 μg of cimetidine (a selective H 2-receptor antagonist) but was not affected by 100 μg of chlorpheniramine (a selective H 1-receptor antagonist). These result suggest that clonidine can dilate the isolated and perfused canine coronary arteries by acting on histamine H 2-receptors.
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