Abstract
In the present study, effects of the serotonergic system of the dorsal hippocampus (CA1) on harmaline-induced amnesia were examined. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-peritoneal (i.p.) administration of harmaline (1mg/kg) induced impairment of memory retention. Moreover, intra-CA1 administration of 5-HT1B/1D receptor agonist, CP94253 (5ng/mouse), 5-HT1B/1D receptor antagonist, GR127935 (0.05 and 0.5ng/mouse), 5-HT2A/2B/2C receptor agonist, α-methyl 5-HT (0.5ng/mouse) and 5-HT2 receptor antagonist, cinancerine (0.5ng/mouse) impaired memory acquisition, but did not affect locomotor activity and tail flick. Furthermore, pre-training intra-CA1 injection of subthreshold dose of CP94253 (0.05ng/mouse) or GR127935 (0.005ng/mouse) reversed impairment of memory acquisition induced by harmaline (1mg/kg, i.p.). However, pre-training intra-CA1 infusion of subthreshold dose of α-methyl 5-HT (0.005ng/mouse) or cinancerine (0.005ng/mouse) with the administration of harmaline (0.5 and 1mg/kg, i.p.) heighten impairment of memory acquisition. These findings implicate the involvement of CA1 serotonergic mechanism in harmaline-induced impairment of memory acquisition.
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