Abstract
Abstract Linkage between genes regulating the serum levels of complement (C) components and those governing the expression of major histocompatibility complex (MHC) antigens has been reported in man. The latter include HL-A and the antigens regulating allogeneic recognition in the mixed lymphocyte reaction (MLR). These findings prompted us to investigate whether C components might be related to MHC antigens on the cell surface and participate in cellular immune recognition phenomena. Cultured human lymphoid cells absorbed anti-C4 activity from several antisera in a dose-related manner, suggesting the presence of C4 on the cell surface. However, no evidence for secretion of C4 was found. No relationship between C4 and HL-A antigens was observed as 1) lymphoid cells coated with antisera to C4 were unimpaired in their ability to specifically absorb antibodies to HL-A antigens, 2) nine C4 preparations did not deplete cytolytic potential from HL-A antisera, and 3) no anti-C4 activity was detected in HL-A alloantisera.
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