Possibilities of proteolytic enzymes in the treatment of some forms of male infertility

Abstract

In the study 46 men with impaired fertility and the presence of viscosipathy were included. The patients age ranged from 22 to 45 years, the average duration of infertility in marriage was 3.5 2.4 years. All patients with Longidaza drugs according to the following scheme were treated. First, ten intramuscular injections of Longidaza lyophilisate were performed to prepare a solution of 3000 IU once every five days, then Longidaza suppositories 3000 IU rectally once every three days were prescribed, for a total of 15 suppositories. The total duration of the course of treatment is 90 days. A decrease in sperm viscosity from 2.1 0.05 cm to 0.6 0.07 cm (p 0.05), an increase in total sperm motility (from 32.6 2.9 to 61 3.1%, p 0.05) and the number of sperm with progressive movement (from 22 1.1 to 36.7 2.9 %, p 0.05) after the treatment were revealed. Also, in the course of treatment, the restoration of the antioxidant protection of the ejaculate was noted, as evidenced by an increase in the activity of glutathione peroxidase and superoxide dismutase and a decrease in the content of malon dialdehyde. During the first year after the end of treatment, conception in marriage was registered in 21 (45.7%) patients. The results of the study indicate that a violation of the lipid peroxidation system can lead to both an increase in sperm viscosity and a disruption in the activity of acrosomal enzymes, as a result of which it becomes difficult for spermatozoa to penetrate the ovum. Longidaza is able to increase the hyaluronidase activity of the sperm acrosome, thereby improving the fertilizing ability of the ejaculate.