Abstract

Abstract Repeated positive fighting experience allows forming aggressive types of behavior in male mice of different strains under the influence of social victories in daily agonistic interactions. This report summarizes and analyzes the results of >30-year studies of repeated experience of aggression with winning outcomes and its effects on the behaviors, psychoemotional state and neurochemical changes in the brain of experienced winners. Special emphasis will be given to the utility of this approach for the experimental study of the neural mechanisms of pathological aggression. It was shown that development of addiction-like state under positive fighting experience is one of the mechanisms of aggression relapse.

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