Abstract
The aim of this study was to evaluate the association of education and tau burden in patients with clinical probable Alzheimer's disease (AD). We recruited 26 AD patients. We used education year as a proxy of cognitive reserve. The amyloid positivity was assessed by [18F]-florbetaben PET. Tau was assessed using [18F]THK-5351-PET for all patients at Samsung or Asan Medical Center. Cerebellar gray matter was used as a reference region and we measured regional tau standardized uptake value ratio (SUVR). We used freeSurfer-derived ROIs. In logistic regression, amyloid positivity was not correlated with education years significantly. However, education years were positively correlated with [18F]THK-5351 SUVR in the left lingual and left superior temporal region (p = 0.024 and 0.029, respectively). Our results show that AD with higher education had suffered more pronounced tau burdens in specific parts of the brain than AD with lower education, which may be related to cognitive reserve theory.
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