Abstract
Kidney disease is a frequent presentation of patients with Multiple myeloma. There is scant data of clinical presentation and final outcomes of patients with multiple myeloma and renal disease in India. Aim of this study : To study the clinical profile and outcomes of patients with Multiple myeloma and kidney disease in a tertiary care center in West India. It is a retrospective, observational study of patients attending Muljibhai Patel Urological hospital, Nadiad, India from November 2017 till June 2020. Inclusion criteria: • All patients with clinical diagnosis of multiple myeloma based on bone marrow, renal histology and serological analysis • Presence of kidney disease : eGFR <60 ml/min and /or UPCR > 1 or abnormal renal biopsy Exclusion criteria: • Patients without kidney disease or patients without multiple myeloma • Outcomes which were analyzed were • Death • ESRD status • History of chemotherapy • Clinical remission • 63 patients were enrolled • Average age was 61.53 ± 10.26 years • 42 males and 21 females. Common symptoms were weakness , Easy fatigability , Bone pain/ backachePresenting feature Oliguria in 15 (23.8 %)History of NSAID intake in 22 (34.9 %) Hematuria in 5 (7.9%) oHistory of hypertension or were on antihypertensive medication 30(47.6%) Lab investigation : Albumin/ Globulin ratio < 1 was seen in 61 pts (73%) Anemia (<12 gm/dl) in (92 %) Hypercalcemia (corr. Calcium > 10.5 mg/dl )in 30 (47.6 %) • Of the 55 patients who were available for telephonic follow up since onset of study 24 (43.63%) had died 16 (29.09%) were dialysis dependent 41(74.54%) received chemotherapyView Large Image Figure ViewerDownload Hi-res image Download (PPT) Majority of patients with myeloma present in 6th decade with severe renal failure and reversed A:G ratio, with nearly half having hypercalcemia and anemia. Majority undergo chemotherapy but nearly 30 % suffer from ESRD and 4 out of 10 die.
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