Abstract
BackgroundMalformations of the cerebral cortex are often associated with developmental delay and psychoses. Porencephaly is a rare congenital disorder of central nervous system involving a cyst or a cavity filled with cerebrospinal fluid, in brain's parenchyma.Case presentationWe present a 25 years old woman with her first psychotic episode. She also suffers from porencephaly in the frontotemporal lobes region. It is emphasized that the two consistently abnormal brain regions in schizophrenia research had significant damage in this patient since birth. There is a total of only five cases of schizencephaly or porencephaly associated with psychosis in the scientific literature. Their clinical characteristics as well as the imaging results are described.ConclusionIt is unclear if porencephaly and psychosis concur by chance or are causally related. The area where the porencephalic cysts appear seems to be of relevance. This case highlights the need for further research.
Highlights
Malformations of the cerebral cortex are often associated with developmental delay and psychoses
It is unclear if porencephaly and psychosis concur by chance or are causally related
The area where the porencephalic cysts appear seems to be of relevance
Summary
Malformations of the cerebral cortex are often associated with developmental delay and psychoses. The present case had clinical manifestation of porencephaly, i.e. mild mental retardation and spastic paresis in her left arm accompanied by motor impairment This patient did not have speech development problems or seizures. Pae et al in 2009 report the case of a patient who developed a psychotic episode, possibly, associated with multiple leukoencephalomalacia and Porencephaly changes in the brain cortex. In this case, a 30-year-old woman had persecutory ideas and visual hallucination. Alves da Silva et al described the case of a patient with an arachnoid cyst in the left temporal lobe He had psychotic symptoms such as delusions and hallucinations [16]. Douzenis et al 1 2009 a large porencephalic cyst on the left frontal and temporal lobes
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