Abstract
ALTHOUGH most investigators have concluded that protein polymorphisms are maintained by balancing selection1,2, some contend that they are the consequences of random drift of neutral or nearly neutral alleles3,4. Many empirical data seem to support the selectionist view, although the mechanism that might be involved is not well understood. In any case, critical data on changes in allelic or genotypic frequencies through time are not available for most natural populations. Therefore, the major evidence for selective responses is provided by deviations from expected zygotic proportions at some given time.
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