Abstract
BackgroundThe vast majority of research in the area of community-acquired pneumonia (CAP) has been based on patients admitted to hospital. And yet, the majority of patients with CAP are treated on an ambulatory basis as outpatients, either by primary care physicians or in Emergency Departments. Few studies have been conducted in outpatients with pneumonia, and there is a paucity of data on short and long term morbidity or mortality and associated clinical correlates in this group of patients.MethodsFrom 2000–2002, all CAP patients presenting to 7 Emergency Departments in Edmonton, Alberta, Canada were prospectively enrolled in a population-based registry. Clinical data, including pneumonia severity index (PSI) were collected at time of presentation. Patients discharged to the community were then followed for up to 5 years through linkage to the provincial administrative databases. The current report provides the rationale and design for the cohort, as well as describes baseline characteristics and 30-day morbidity and mortality.ResultsThe total sample included 3874 patients. After excluding patients who were hospitalized, died or returned to the Emergency Department the same day they were initially discharged (n = 451; 12 %), and patients who could not be linked to provincial administrative databases (n = 237; 6 %), the final cohort included 3186 patients treated according to a validated clinical management pathway and discharged back to the community. Mean age was 51 (SD = 20) years, 53 % male; 4 % resided in a nursing home, 95 % were independently mobile, and 88 % had mild (PSI class I-III) pneumonia. Within 30-days, return to Emergency Department was common (25 %) as was hospitalization (8 %) and 1 % of patients had died.ConclusionsTo our knowledge, this represents the largest clinically-detailed outpatient CAP cohort assembled to date and will add to our understanding of the determinants and outcomes in this under-researched patient population. The rich clinical data along with the long term health care utilization and mortality will allow for the identification of novel prognostic indicators. Given how under studied this population is, the findings should aid clinicians in the routine care of their outpatients with pneumonia and help define the next generation of research questions.
Highlights
The vast majority of research in the area of community-acquired pneumonia (CAP) has been based on patients admitted to hospital
In the studies conducted to date, admission to hospital following Emergency Department discharge for CAP is between 1.5-8.5 % within 30-days [6,8,10,12,13]
Setting Between 2000 and 2002 all outpatients with CAP presenting to all 7 Emergency Departments serving Edmonton, Alberta, Canada were enrolled in a population-based clinical registry and treated according to a previously validated clinical management pathway for CAP, and discharged back to the community [17]
Summary
The vast majority of research in the area of community-acquired pneumonia (CAP) has been based on patients admitted to hospital. The majority of patients with CAP are treated on an ambulatory basis as outpatients, either by primary care physicians or in Emergency Departments. Few studies have been conducted in outpatients with pneumonia, and there is a paucity of data on short and long term morbidity or mortality and associated clinical correlates in this group of patients. In Canada, pneumonia accounts for 1 million physician visits and is a major leading cause of death with ~8,000 deaths per year, most of day mortality rate of 0.6 % [6]. In the studies conducted to date, admission to hospital following Emergency Department discharge for CAP is between 1.5-8.5 % within 30-days [6,8,10,12,13].
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