Abstract

Plants constituents are a reliable source of the remedial need of humanity for ages by being the basis of the traditional medicinal system and often serving as the prototype for designing modern medicine. Several plants are used in traditional medicine for ages without proper administration guidelines in terms of dosages. Several toxicological analyses revealed side-effects of such therapies beyond a specific dose. One such plant is Alstonia scholaris, widely used in numerous traditional medicines to treat diseases like ulcers, asthma, diabetes, etc. The present study investigated the neurotoxic effect of the plant extract through oxidative stress in Swiss albino mice. The treated mice showed anxiety, neophobic and depression-like properties compared to control mice. The biochemical parameters show an increase in Malondialdehyde (MDA) concentration while decreasing the total protein content in different brain regions of treated mice. The Glutathione Reductase (GR) activity shows an increase in treated mice compared to the control one. The study indicates that Alstonia scholaris may cause severe damage to the central nervous system when administered without a proper guideline.

Highlights

  • Traditional medicines that primarily include plant-based preparations are the most commonly used source of inexpensive and accessible remedies in many developing countries[1]

  • 3.2 Elevated Plus Maze Test: EPM test was performed to understand the variation of anxiety that occurred in different treated groups

  • The time spent by different groups in the closed arm and open arm of the EPM apparatus is shown in Figure 2 and Figure 3

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Summary

Introduction

Traditional medicines that primarily include plant-based preparations are the most commonly used source of inexpensive and accessible remedies in many developing countries[1]. In developed countries, they are used as alternative medicines either with current therapies for synergistic effect or as a substitute for expensive treatments[2]. The plant's preparations are used widely in traditional therapies, some reports suggest that the doi:10.20944/preprints202104.0764.v1 plant’s extracts may have several acute and chronic toxicity, including oral toxicity[21] and developmental toxicity[22] when used beyond a specific limit. Two doses of the extract (100 and 300 mg/ml) were prepared as a low and high dose by dissolving them in distilled water for oral administration

Experimental Animals
Behavioural studies
Modified Hole Board Test
Forced Swim Test
Biochemical Assays
Total protein estimation
Change in Body weights
Elevated Plus Maze Test
Discussion
Citations:
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