Abstract
Polyurethane foams (PUFs) have attracted attention as biomaterials because of their low adhesion to the wound area and suitability as biodegradable or bioactive materials. The composition of the building blocks for PUFs can be controlled with additives, which provide excellent anti-drug resistance and biocompatibility. Herein, nanosized Cu-BTC (copper(II)-benzene-1,3,5-tricarboxylate) was incorporated into a PUF via the crosslinking reaction of castor oil and chitosan with toluene-2,4-diisocyanate, to enhance therapeutic efficiency through the modification of the surface of PUF. The physical and thermal properties of the nanosized Cu-BTC-incorporated PUF (PUF@Cu-BTC), e.g., swelling ratio, phase transition, thermal gravity loss, and cell morphology, were compared with those of the control PUF. The bactericidal activities of PUF@Cu-BTC and control PUF were evaluated against Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus. PUF@Cu-BTC exhibited selective and significant antibacterial activity toward the tested bacteria and lower cytotoxicity for mouse embryonic fibroblasts compared with the control PUF at a dose of 2 mg mL−1. The Cu(II) ions release test showed that PUF@Cu-BTC was stable in phosphate buffered saline (PBS) for 24 h. The selective bactericidal activity and low cytotoxicity of PUF@Cu-BTC ensure it is a candidate for therapeutic applications for the drug delivery, treatment of skin disease, and wound healing.
Highlights
Polyurethanes (PUs), which can be synthesized by polymerization reactions between isocyanates and polyols, are versatile polymers used in various applications
Polyurethane foams (PUFs)@Cu-BTC was prepared as a film via foaming reaction of castor oil, chitosan, nanosized Cu-BTC, Dabco 33, and water with TDI in 10% excess molar ratio
In this study, nanosized Cu-BTC was successfully incorporated into the PUF surface via a crosslinking process at 25 ◦C to afford PUF@Cu-BTC
Summary
Polyurethanes (PUs), which can be synthesized by polymerization reactions between isocyanates and polyols, are versatile polymers used in various applications. PUs are prepared from petroleum-based resources; with the increasing interest in sustainable and environmental issues, many kinds of sustainable natural materials such as castor oil, crude glycerol, olive stone, lignin, and sorbitol have been used to generate polyols [6,7,8,9,10]. PUs prepared from plant-based polyols provide additional advantages in biocompatibility for biomedical applications [11,12,13,14]. The composition of the building blocks for PUFs can be controlled with additives, which provide excellent anti-drug resistance and biocompatibility [15,16,17,23]
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