Polyurethane based hybrid ciprofloxacin-releasing wound dressings designed for skin engineering purpose

Abstract

PurposeEven in the 21st century, chronic wounds still pose a major challenge due to potentially inappropriate treatment options, so the latest wound dressings are hybrid systems that enable clinical management, such as a hybrid of hydrogels, antibiotics and polymers. These wound dressings are mainly used for chronic and complex wounds, which can easily be infected by bacteria. Materials and methodsSix Composite Porous Matrices (CPMs) based on polyurethane (PUR) in alliance with polylactide (PLAs) and poly(vinyl alcohol) (PVA) were prepared and analyzed using optical microscopy. Three different types of hydrogels and their Ciprofloxacin (Cipro) modified variants’ ratios were prepared and analyzed using FTIR, SEM and EDX techniques. Six Hybrid Cipro-Releasing Hydrogel Wound Dressings (H-CRWDs) were also prepared and underwent short-term degradation, Cipro release, microbiology and cell viability measurements. ResultsAverage porosity of CPMs was in the range of 69–81%. The pore size of the obtained CPMs was optimal for skin regeneration. Short-term degradation studies revealed degradability in physiological conditions regardless of sample type. A meaningful release was also observed even in short time (21.76 ​± ​0.64 ​μg/mL after 15 ​min). Microbiological tests showed visible inhibition zones. Cell viability tests proved that the obtained H-CRWDs were biocompatible (over 85% of cells). ConclusionsA promising hybrid wound dressing was labeled. Simple and cost-effective methods were used to obtain microbiologically active and biocompatible dressings. The results were of importance for the design and development of acceptable solutions in the management of chronic wounds of high potential for infection.