Abstract
The implantation of joint prostheses may lead to infection (about 2% of the cases) with more or less dramatic consequences as morbidity or even death. Several clinical and experimental studies showed the high interest of antibiotic prophylaxis to prevent such infections but also its relative inefficiency when the infection is established. Bioactive polymers bearing anionic groups have synthesized and showed to be able to inhibit bacterial adhesion. In this study, the bioactive polymers were mixed with commercial acrylic orthopaedic cement used in the surgery of total hip prosthesis. We demonstrated that mixtures cement/bioactive polymers may inhibit adhesion of Staphylococcus aureus ( S. aureus) – strain resistant MRSA 88244) by diffusion process. Kinetics of diffusion of the bioactive polymers can be controlled by addition of hydrophobic units as methymethacrylate in the macromolecular chains of the polymers.
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