Abstract
Background: We aimed to investigate the association between single-nucleotide polymorphisms (SNP) in mismatch repair (MMR) pathway genes and survival in patients with oral squamous cell carcinoma (OSCC) who received adjuvant concurrent chemoradiotherapy (CCRT). Methods: Using the Sequenom iPLEX MassARRAY system, five SNPs in four major MMR genes were genotyped in 319 patients with OSCC who received CCRT treatment. Kaplan–Meier survival curves and Cox proportional hazard regression models were used to assess overall survival (OS) and disease-free survival (DFS) among MMR genotypes. Results: The results of Kaplan–Meier survival analysis revealed that the MutS homolog 2 (MSH2) rs3732183 polymorphism showed a borderline significant association with DFS (log-rank p = 0.089). Participants with the MSH2 rs3732183 GG genotype exhibited a relatively low risk of recurrence (hazard ratio (HR) = 0.45; 95% confidence interval (CI) = 0.22–0.96; p = 0.039). In addition, the MutL homolog 1 (MLH1) rs1800734 GG genotype carriers exhibited higher OS (HR = 0.52, 95% CI = 0.27–1.01; p = 0.054) and DFS (HR = 0.49, 95% CI = 0.26–0.92; p = 0.028) rates. Conclusions: Our results indicated that the GG genotypes of MSH2 rs3732183 and MLH1 rs1800734 are associated with relatively high survival in OSCC patients treated using adjuvant CCRT. These polymorphisms may serve as prognosis predictors in OSCC patients.
Highlights
3% of all cancers occur in the oral cavity; approximately 90% of all oral cancers (OCs) are oral squamous cell carcinoma (OSCC), which is one of the most prevalent cancers and the fourth commonest causes of cancer mortality among men in Taiwan [1]
Given that different treatments may cause varying DNA damage and exhibit different repair efficacy, we investigated the association between polymorphisms and outcomes in OSCC patients who received identical treatment with adjuvant concurrent chemoradiotherapy (CCRT) and exhibited similar disease stages
319 male patients with OSCC were recruited to explore the effects of genetic variants of MMR genes on the risk of death or recurrence
Summary
3% of all cancers occur in the oral cavity; approximately 90% of all oral cancers (OCs) are oral squamous cell carcinoma (OSCC), which is one of the most prevalent cancers and the fourth commonest causes of cancer mortality among men in Taiwan [1]. Despite advancements in the diagnosis and treatment of OSCC, the 5-year overall survival (OS) rate, which is currently 56.6%, has not improved significantly in the past decades [1]. Adjuvant treatments of chemotherapy and radiotherapy (RT) with surgery are used to treat advanced stages of OSCC, depending on the overall health status of the patients and invasive pathological parameters [2,3]. The 5-year survival rate among patients with advanced stages of OSCC is low, and most patients die in the first 30 months of the disease [4,5]. We aimed to investigate the association between single-nucleotide polymorphisms (SNP) in mismatch repair (MMR) pathway genes and survival in patients with oral squamous cell carcinoma (OSCC) who received adjuvant concurrent chemoradiotherapy (CCRT)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
