Abstract
Long noncoding RNAs (lncRNAs) are a new class of potential biomarkers and therapeutic targets for cancer. In this study, we chose four single nucleotide polymorphisms (SNPs) in lncRNA-PCAT1 (rs1026411 G>A, rs12543663 A>C, rs710886 T>C, and rs16901904 T>C) to investigate the association between genetic variant in lncRNA-PCAT1 and susceptibility to lung cancer. The study was a hospital-based case–control study including 561 cancer-free controls and 468 lung cancer cases. Genotyping of four SNPs was conducted by using Taqman® allelic discrimination methods. All statistical analyses were performed by using IBM SPSS Statistics 22 software. We failed to find significant associations between four SNPs and lung cancer risk in all models. However, polymorphisms in rs1026411 and rs710886 were observed to have significant associations with susceptibility to non-small cell lung cancer (AG vs. GG: odds ratio [OR]a = 0.701, p* = 0.020 and AA+AG vs. GG: ORa = 0.711 [superscript “a” refers to OR adjusted by age, gender, and smoking], p* = 0.017 [asterisks “*” refers to p adjusted by age, gender, and smoking] for rs1026411; CT vs. TT: ORa = 0.723, p* = 0.047 and CC+CT vs. TT: ORa = 0.729, p* = 0.038 for rs710886). Besides, the rs1026411 polymorphism had a similar association with lung adenocarcinoma risk (AG vs. GG: ORa = 0.663, p* = 0.019 and AA+AG vs. GG: ORa = 0.685, p* = 0.020). Polymorphisms in rs710886 and rs16901904 were observed to be associated with lung squamous cell carcinoma risk (CC+CT vs. TT: ORa = 0.638, p* = 0.040 for rs710886; CC vs. TT: ORa = 2.582, p* = 0.033 and CC vs. TT+CT: ORa = 2.381, p* = 0.048 for rs16901904). In addition, there were no significant results in gene–environmental interactions in both additive and multiplicative models. Our results suggested that polymorphisms in lncRNA-PCAT1 might be associated with lung cancer susceptibility in a northeastern Chinese population. The results of gene–environmental interactions were not significant in lung cancer.
Highlights
Worldwide, lung cancer remains the leading cause of cancer morbidity and mortality for men and women, with 2.1 million new lung cancer cases (11.6% of the total cancer cases) and 1.8 million deaths (18.4% of the total cancer deaths) predicted in 2018, according to GLOBOCAN 2018 produced by the International Agency for Research on Cancer (Bray et al, 2018)
The case group was composed of 468 lung cancer patients, including 243 lung adenocarcinoma cases, 155 squamous cell carcinoma cases, and 61 small-cell lung cancer cases
We found that polymorphisms in lncRNAPCAT1 had a significant association with lung cancer risk
Summary
Lung cancer remains the leading cause of cancer morbidity and mortality for men and women, with 2.1 million new lung cancer cases (11.6% of the total cancer cases) and 1.8 million deaths (18.4% of the total cancer deaths) predicted in 2018, according to GLOBOCAN 2018 produced by the International Agency for Research on Cancer (Bray et al, 2018). Smoking cannot clarify all etiologies of lung cancer, which suggested that other environmental risk factors or genetic risk factors might play critical roles in lung carcinogenesis. Human genome sequencing has found that protein-coding genes accounted for 3% of human DNA; more than 80% of our genome are actively transcribed into a miscellaneous group of RNA transcripts without potentiality for protein coding (Djebali et al, 2012; ENCODE Project Consortium, 2012; Martens-Uzunova et al, 2014). These transcripts were called noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs) and small noncoding BI ET AL.
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