Abstract
Diabetes is a major public health problem because it is world’s sixth cause of death. An inflammatory disease that associated with many inflammatory markers, which is a key for complications of vascular endothelial system, literally for high risk populations. Some adhesion molecules were studied in the sera of Iraqi Arab female as P-selectin associated with inflammatory disease and Cytokines. This work tend to evaluate the association between soluble P-selectin level, polymorphism for mutation site 2123C/G (rs1800807) and the role of P-selectin and IL-4 polymorphism in the developing of Diabetes Mellitus type 2. Genetic polymorphism of P-selectin gene was investigated at the position -2123C/G, Present study illustrated three genotypes (GG, GC, CC), with the significant protective effect for G allele and Etiological effect for C allele. The Polymorphism of IL-4- gene at the position IL-4 -1098 was presented with three genotypes (TT, TC and CC), Furthermore the result of C allele frequency (RR=1.45 with EF=0.312) reflect an Etiological effect for C allele with positive association with disease. All present factors in the first view may occur as independent risk factors but after a deeply focusing on results, it seems as if there’s a sequence functions among them, the result in a synergist effect interfere with Diabetes Mellitus type 2
Highlights
C/G-2123 والذي اختیر عند الموقعp-selectin تعدد الاشكال الوراثي لعامل الالتصاق. وتطور مرض السكري-1098 عند الموقع4 ابیضاضي في حین تعدد.C وتاثیرا وبائیا للالیلG ( وظھر تاثیرا وقائیا معنویا للالیلGG, GC, CC) في الدراسة الحالیة لھ ظھرت ثلاثة تراكیب وراثیة دوره الوبائيC ( وعكست نتائج تكرار الالیلTT, TC, CC) اظھر ثلاثة تراكیب وراثیة ھي1098- الاشكال لجین البین ابیضاضي عند الموقع كل العوامل الحالیة للوھلة الاولى تظھر وكانھا عوامل خطورة مستقلة عن بعضھا البعض لكن بعد التدقیق في.والارتباط الموجب مع المرض
An inflammatory disease that associated with many inflammatory markers, which is a key for complications of vascular endothelial system, literally for high risk populations [1]
Cytokines play a key roles in the pathogenesis of diabetes in which the pattern of cytokine expression are changed, as well as many researchers in immune and genetics field believed that DMT2 is associated with cytokine imbalance and alter pattern of Th2 to Th1 immune response [11], as well as a previous study suggested that gene polymorphisms of IL-4 play an important role in the pathogenesis of diabetic nephropathy in Iranian patients with DMt2[12]. it become so important to investigate the role of genetics polymorphism for P-selectin with IL-4 in the developing of Diabetes Mellitus type 2
Summary
Polymorphism of P-selectin (- 2123C/G, rs1800807 C/G) and IL-4 -1098 in a sample of Iraqi Diabetes Mellitus Type 2. في4 لجین البین ابیضاضي1098 والموقعC/G 2123 عند الموقعP-selectin تعدد الاشكال الوراثیة للعامل عینة من العراقیات المریضات بالسكري من النوع الثاني. Expression of present factor is induced by two distinct mechanisms It is synthesized by megakaryocytes and endothelial cells, it is sorted into the membranes of secretory granules. [6] When megakaryocytes and endothelial cells are activated by agonists such as thrombin, it rapidly translocated to the plasma membrane from granules.[7] Secondly, increased levels of Pselectin mRNA and protein are induced by inflammatory mediators such as tumor necrosis factor-a (TNF-a), LPS, and interleukin-4 (IL-4). Cytokines play a key roles in the pathogenesis of diabetes in which the pattern of cytokine expression are changed, as well as many researchers in immune and genetics field believed that DMT2 is associated with cytokine imbalance and alter pattern of Th2 to Th1 immune response [11], as well as a previous study suggested that gene polymorphisms of IL-4 play an important role in the pathogenesis of diabetic nephropathy in Iranian patients with DMt2[12]. it become so important to investigate the role of genetics polymorphism for P-selectin with IL-4 in the developing of Diabetes Mellitus type 2
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