Polymorbidity and heterogeneity of intact bone tissue in patients with malignant and metastatic bone tumors

Abstract

Polymorbidity is the presence of several synchronically occurring diseases (genetically or pathogenetically related or unrelated) in one person at different stages and phases of their development, is accompanied by higher mortality rates, higher disability rates, treatment side effects, increased consumption of the patient’s body resources, lower quality of life. The purpose of the article is to demonstrate the association of polymorbidity and intact bone tissues’ heterogeneity in patients with malignant and metastatic bone tumors. Material and methods. 16 patients with benign bone tumors, 25 – with primary malignant bone tumors and 22 – with metastatic bone tumors were investigated with multispiral tomography scanner: 33 (52.4 %) men and 30 (47.6 %) women aged 25 to 75 years. The control group consisted of 37 patients with suspected tumor lesions of the bones, but the diagnosis was not confirmed. To assess polymorbidity in patients, the CIRS-G system was applied. Conclusion. An increase in polymorbidity level is associated with a decrease in RGD and an increase in the texture heterogeneity of computed tomographic images of the spongy and compact bones (the pattern is reliable, P <0.01) in the series: practically healthy individuals, patients with benign tumors, patients with malignant tumors, patients with metastatic tumors.