Abstract
Introduction: Polymicrogyria, the appearance of irregular small and over numbered gyri on the surface of the brain, has been reported as the most frequent finding, when exists, on the temporal lobe. Case Presentation: A patient, male, age of 35, came to the regular head and brain MRI scan due to psychiatric and hormonal treatment within transsexualism. There were no data of epilepsy in a patient’s history. MRI scans were acquired with a 1.5 T Siemens Magnetom system with a standard head coil. Three-dimensional 3D RAGE, contiguous 1.0 mm slice, and 1 acquisition sequence underwent final 3D rendering and subsequent volumetry. On the definitive 3D image, we have revealed an unusual gyrisation on the left temporal lobe which had a picture of partial polymicrogyria. Conclusion: This is a unique finding, to our knowledge, of the unilateral temporal polymicrogyria in a person with transsexualism. Although polymicrogyria is mostly related to epileptifom attacks, its impact on the transsexualism appearance is opened to be examined.
Highlights
IntroductionTranssexuality is characterized by a strong conviction of having been born in the wrong body and is considered to be the extreme end of the spectrum of gender identity disorders characterized by a pursuit of sex reassignment surgery [1]
Polymicrogyria, the appearance of irregular small and over numbered gyri on the surface of the brain, has been reported as the most frequent finding, when exists, on the temporal lobe
Studies in humans have shown that levels of circulating sex steroids and estrogen feedback on luteinizing hormone do not differ between transsexuals and controls [9,10,11]
Summary
Transsexuality is characterized by a strong conviction of having been born in the wrong body and is considered to be the extreme end of the spectrum of gender identity disorders characterized by a pursuit of sex reassignment surgery [1]. Female-to-male transsexuals and male-to-female transsexuals are characterized by persistent male or female identification and constant feeling of being trapped in the wrong body, which is seems to be their permanent kind of a obsessive thought and final life goal as gender identification is the basic human psychological characteristics. Polymicrogyria is one of the most common malformations of cortical development. It is often associated with specific syndromes, and has a wide variety of clinical presentation [2,3,4]. It is mostly related to epileptic attacks, and its impact on the transsexualism appearance is opened to be examined
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