Abstract
Polymeric micelles are one of the most refined and promising modalities of macromolecular drug delivery systems , and show unique disposition characteristics in the body suitable for the drug targeting (e.g., prolonged blood circulation and significant tumor accumulation as described in earlier chapter) . Like the other promising modalities (i.e., watersoluble polymers and long-circulating liposomes), the polymeric micelle carrier systems might possess several advantages such as (1) the applicability to a variety of therapeutic agents (e.g., hydrophobic compounds, metal complexes and charged macromolecules such as polypeptides and nucleic acids), (2) unnecessariness of chemical structure
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