Abstract
Copolymers of N-(2-hydroxypropyl)methacrylamide with p-nitrophenyl esters of unsaturated phenoxyacetic acids and N-methacryloylglycylleucine and with acrylic acid were synthesized as polymer carriers for obtaining water-soluble polymer forms of an antibiotic gramicidin-S. The kinetics of the aminolysis of copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) which contain reactive p-nitrophenoxycarbonyl groups by gramicidin-S were investigated. It was established that aminolysis rate depends on the structure of the bridge group which binds p-nitrophenoxycarbonyl group to the main chain of the copolymer. On the basis of these copolymers of HPMA polymer amide and salt derivatives of gramicidin-S were obtained and their composition was determined. It was shown, that the antibacterial activity of these polymer derivatives of gramicidin-S depends on the bond type of the antibiotic with the polymer and attains a relatively high level for polymer salts of gramicidin-S.
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