Polyethylene glycol functionalized carbon nanotubes/gelatin-chitosan nanocomposite: An approach for significant drug release

Abstract

This research work blooms the new idea of developing a safe and controlled drug releasing matrix using multi-walled carbon nanotubes (MWCNTs). In aqueous solution, uniform and highly stable dispersion of MWCNTs was obtained after secondary functionalization with polyethylene glycol (PEG) which was studied by Fourier transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). Solution casting method was used to prepare MWCNTs/gelatin-chitosan nanocomposite films and the effect of MWCNTs on physico-mechanical, thermal and water uptake properties of the nanocomposites were evaluated. Incorporation of MWCNTs into the porous gelatin-chitosan matrix showed interesting stiffness and dampness along with developed microfibrillar structures within the pore walls intended at being used in tissue engineering of bone or cartilage. A common antibiotic drug, ciprofloxacin was incorporated into nanocomposite matrix. The evaluation of the effect of MWCNTs on drug release rate by dissolution test and antimicrobial susceptibility test was performed. Sharp release of the drug was found at early stages (∼1 h), but the rate was reduced afterwards, showing a sustained release. It was observed that for all microorganisms, the antibacterial activities of drug loaded MWCNTs/gelatin-chitosan nanocomposites were higher than that of drug loaded gelatin-chitosan composite films containing no MWCNTs. Comparative statistical studies by ANOVA techniques also showed remarkable difference between the antibacterial activities, exhibited by MWCNTs-incorporated and non-incorporated composite films.