Abstract
Silk sericin (SS) is a type of natural macromolecular protein with excellent hydrophilicity, biocompatibility and biodegradability, but also has very poor mechanical properties. To develop sericin-based wound dressings, we utilized polyvinyl alcohol (PVA) to reinforce the mechanical property of sericin by blending PVA and sericin, then modified zinc oxide nanoparticles (ZnO NPs) on SS/PVA film with the assistance of polydopamine (PDA) to endow SS/PVA film with antibacterial activity. Scanning electron microscopy, energy dispersive spectroscopy and X-ray powder diffraction demonstrated ZnO NPs were well grafted on PDA-SS/PVA film. Fourier transform infrared spectra suggested PDA coating and ZnONPs modification did not alter the structure of sericin and PVA. Water contact angle and swelling tests indicated the excellent hydrophilicity and swellability of ZnO NPs-PDA-SS/PVA composite film. Mass loss analysis showed ZnO NPs-PDA-SS/PVA film had excellent stability. The mechanical performance test suggested the improved tensile strength and elongation at break could meet the requirement of ZnO NPs-PDA-SS/PVA film in biomaterial applications. The antibacterial assay suggested the prepared ZnO NPs-PDA-SS/PVA composite film had a degree of antimicrobial activity against Escherichia coli and Staphylococcus aureus. The excellent hydrophilicity, swellability, stability, mechanical property and antibacterial activity greatly promote the possibility of ZnO NPs-PDA-SS/PVA composite film in antibacterial biomaterials application.
Highlights
Wound dressing has a variety of functions, of which the first is to prevent continued bleeding through a certain degree of mechanical compression
PDA has excellent biocompatibility, biodegradability and hydrophilicity [27]. Taking advantage of these features, PDA could facilitate zinc oxide nanoparticles (ZnO NPs) being deposited on the Silk sericin (SS)/polyvinyl alcohol (PVA) composite film to endow it with antibacterial properties
The surface morphology of Zinc oxide (ZnO) NPs-PDA-SS/PVA, PDA-SS/PVA and SS/PVA films were imaged on a JSM-5610LV scanning electron microscopy (Tokyo, Japan) with a working voltage of
Summary
Wound dressing has a variety of functions, of which the first is to prevent continued bleeding through a certain degree of mechanical compression. Bacteria can enter into the deeper skin layers through wounds [16] It is required for sericin/PVA (SS/PVA) film to have the ability of preventing bacterial infection. It has the catechins and amino groups with high affinity for metal ions, which can be used both as an ideal molecule covalent modification of starting point and a transition metal ions load anchor These functional groups can pass on the basic properties of metal ions under the condition of having a strong restorative ability to further realize the emergence of a variety of mixed material [25]. PDA has excellent biocompatibility, biodegradability and hydrophilicity [27] Taking advantage of these features, PDA could facilitate ZnO NPs being deposited on the SS/PVA composite film to endow it with antibacterial properties. 24, 503 of the composite film against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus)
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