Abstract
Serum IgG from autoimmune MRL/MP- lpr/lpr(MRL/l) mice induced IL-3 mRNA, IL-3 synthesis, and cell proliferation in the IL-3-dependent cell line, FDC-P2/185-4. Cell growth, induced by MRL/ l-IgG, was suppressed by anti-IL-3 antibody, suggesting an automne mechanism. We established hybridomas from the splenocytes of a nonimmunized MRL/ l mouse. The mAbs, produced by these hybridomas, also stimulated IL-3 synthesis and cell growth in FDC-P2/185-4 cells. Both anti-IgG-Fc antibody and anti-FcγRII mAb, 2.4G2 suppressed the cell growth induced by these mAbs. Our results suggest that some IgGs of MRL/ l mice may induce IL-3 synthesis in cells by binding to Fc receptors.
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