Abstract
Polycaprolactone (PCL) microparticles were prepared by an emulsification-solvent evaporation technique using various stabilizers such as gelatin, hydrophobically modified polyacrylamide derivative (PAM) and poly(vinyl alcohol) (PVA). It was shown that the particle size distribution of PCL microparticles was 13.4±4.7 (μm) in diameter with gelatin as stabilizer. The degradation behavior of the PCL microparticles was determined and compared with that of PCL film at pH 7.4 at 37±1°C with and without lipase. The shape of PCL had no obvious effect on its degradation rate. It suggested that homogeneous degradation dominated the process. The degradation rate of PCL microparticles was enhanced in the presence of lipase enzyme. The degree of crystallinity of PCL microparticles increased with degradation, proving preferential degradation in amorphous domains of the PCL microparticles.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
